Randomized angiographic trial of recombinant tissue-type plasminogen activator (alteplase) in myocardial infarction
نویسندگان
چکیده
منابع مشابه
Recombinant Tissue-Type Plasminogen Activator (Alteplase) for Ischemic Stroke
THE FOOD AND DRUG ADMINIStration (FDA) approval in June 1996 of intravenous recombinant tissue-type plasminogen activator (rt-PA) for patients with acute ischemic stroke treated within 3 hours of symptom onset marked a historic first step in treating this devastating disease. This approval was primarily based on the results of the National Institute of Neurologic Disorders (NINDS) trials (1 and...
متن کاملVentricular arrhythmias during treatment with alteplase (recombinant tissue plasminogen activator) in suspected acute myocardial infarction.
Continuous electrocardiography during the first 24 hours of a stay in a coronary care unit was used to record ventricular arrhythmias during treatment with alteplase (recombinant tissue plasminogen activator) or placebo. Recordings were made on 378 of the 436 patients admitted to a double blind trial of alteplase or placebo in one participating centre of the Anglo-Scandinavian study of early th...
متن کاملLingual haematoma after treatment with alteplase (recombinant tissue plasminogen activator) for acute myocardial infarction.
A 69 year old previously healthy man was admitted with a 40 minute history of chest pain. The electrocardiograph showed evidence of an acute anterolateral myocardial infarction (MI). He was treated with soluble aspirin (300 mg), heparin (5000 units bolus), alteplase (rtPA) (100 mg), and heparin infusion (1000 units/h). An hour and 50 minutes later he complained of a dry mouth and examination sh...
متن کاملCombination of Single-Chain Urokinase-Type Plasminogen Activator and Recombinant Tissue-Type Plasminogen Activator in Acute Myocardial Infarction
The effects of simultaneous intravenous infusions of 12 mg recombinant tissue-type plasminogen activator (rt-PA) over 30 minutes and 48 mg single-chain urokinase-type plasminogen activator (scuPA) over 40 minutes were studied in 38 patients with acute myocardial infarction. Coronary arterial patency was assessed angiographically 60 minutes and 90 minutes after initiation of treatment. Patency w...
متن کاملTreatment of acute myocardial infarction with recombinant tissue-type plasminogen activator.
In Ireland, to date, coronary thrombolytic therapy has been confined almost exclusively to the use of streptokinase. However, a large body of evidence suggests that, in comparison to streptokinase, the agent recombinant tissue-type plasminogen activator (rt-PA) may be more effective in lysing coronary thrombi and achieving coronary reperfusion and causes fewer disturbances of the coagulation sy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1992
ISSN: 0735-1097
DOI: 10.1016/0735-1097(92)90131-6